CRDMO platform
From Lab to Market
End-to-End Development and Manufacturing
At Promethea Biochem Solutions, our role as a Contract Research, Development, and Manufacturing Organization (CRDMO) is to transform partner innovation into scalable, sustainable solutions. We provide in-house services spanning DES-based extraction, stabilization, solubilization, encapsulation, formulation, and process scale-up — with production capacity up to pilot scale.
Through open collaboration with academia and a trusted global manufacturing network, we extend this pathway to deliver full end-to-end support: from early R&D to large-scale industrial production. This integrated approach ensures that every project is not only scientifically rigorous but also reliable, compliant, and released on the market — delivering scalable biochemical product development from lab to market.
Our CRDMO Services
Deep Eutectic Solvents (DES) Applications
We develop and apply deep eutectic solvent systems for the extraction, solubilization, and stabilization of active ingredients. By replacing conventional solvents with DES, we offer partners sustainable, safe, and highly efficient alternatives. Our DES applications improve yield, preserve bioactivity, and enhance solubility for otherwise challenging molecules. With custom design tailored to each project, DES technologies enable greener extraction processes, robust stabilization of sensitive actives, and optimized delivery in formulations. These innovations reduce reliance on petrochemical solvents while opening new pathways for product development across agrifood, cosmetics, and industrial markets.
Micro- and Nano-Encapsulation
Our CRDMO platform provides advanced encapsulation technologies designed to protect, stabilize, and control the release of active ingredients. Using both micro- and nano-scale encapsulation, we improve bioavailability, extend shelf life, and enable targeted delivery of actives. Our systems are flexible and customizable, addressing challenges such as solubility, volatility, or degradation. From polymers to lipid-based carriers, we develop encapsulation strategies that are sustainable, reproducible, and scalable. With in-house development and pilot-scale production, we ensure smooth transfer from laboratory prototypes to industrial-ready formulations.
Custom Formulations
We design tailored formulations that meet specific functional, regulatory, and market requirements. Our expertise covers emulsions, suspensions, gels, powders, and other delivery systems, enabling us to adapt chemistry to diverse industrial applications. Each formulation is optimized for stability, performance, and scalability, with sustainability embedded in every step. By combining proprietary R&D with collaborative problem-solving, we co-create products that meet industry standards while offering competitive differentiation. Pilot-scale production capacity ensures that partners can test, validate, and transition seamlessly into larger-scale manufacturing.
Active Extractions
We specialize in the green extraction of active ingredients from botanical and algal sources. Using technologies like DES and optimized processing, we maximize yield while preserving bioactivity and functionality. Our extraction services focus on sustainability and efficiency, reducing environmental footprint compared to conventional solvents. From agrifood bioactives to cosmetic actives, we deliver extracts that are reproducible, high-quality, and ready for formulation. Each project is tailored, ensuring compatibility with partner needs and regulatory standards. Pilot-scale capability allows rapid validation, bridging the gap between lab innovation and market readiness.
Production Process Scale-Up
We support partners in translating laboratory protocols into robust industrial-scale processes. By embedding scalability, reproducibility, and regulatory compliance from the start, we minimize risks and shorten timelines. Our team develops optimized workflows for synthesis, formulation, and encapsulation processes, ensuring efficiency without compromising quality. Pilot-scale validation bridges the critical gap between small-scale experiments and industrial production, de-risking investments while ensuring consistent performance.
Pilot-Scale Production
Our facilities enable pilot-scale production, offering partners the opportunity to test and validate new products under conditions close to industrial operations. This stage is essential for assessing performance, reproducibility, and compliance before committing to full-scale manufacturing. With flexible systems and expert support, we provide cost-effective pilot runs that simulate industrial conditions, generate regulatory dossiers, and ensure smooth transfer to our global manufacturing partners for scale-up.
Open Collaboration & Global Network
Beyond our internal capabilities, we extend CRDMO services through academic collaborations and our global network of GMP/ISO-certified manufacturing partners. This ensures that every project can scale seamlessly — from early-stage research to commercial production — without partners needing to build heavy infrastructure. Our open model provides flexibility, cost-efficiency, and global reach, making us a trusted partner for sustainable innovation.
CRDMO to reimagine chemistry
Our CRDMO services deliver solutions that are:
- Comprehensive: spanning DES applications, encapsulation, formulations, extractions, scale-up, and pilot production.
- Collaborative: fueled by open partnerships with academia, startups, and industry.
- Reliable: validated for safety, compliance, and industrial feasibility from the start.
- Scalable: supported by a global GMP/ISO-certified manufacturing network.
- Sustainable: designed to reduce environmental footprint while enhancing performance.